Men in the lowest quartile of serum adiponectin had a 3.72-fold higher risk of developing new-onset hypertension compared to those in the highest quartile.
Cohort (n=391)
No
Are low serum adiponectin levels associated with an increased risk for the development of hypertension?
Hypoadiponectinemia is an independent, novel predictor for the development of hypertension.
Odds Ratio: 3.72 (95% CI 1.41–9.84)
Absolute Event Rate: 19.4% vs 6.1%
Adiponectin is a recently discovered protein that seems to be exclusively secreted by adipocytes and is the most abundant adipose tissue-derived protein. While some recent studies have demonstrated an association between adiponectin levels and hypertension, these studies were cross-sectional in design, and the results have been inconsistent. Therefore we performed a prospective study to elucidate the role of adiponectin in the development of hypertension. The results of this study showed that serum adiponectin levels were significantly lower in hypertensive subjects than in normotensive subjects. Moreover, in logistic regression analysis, the subjects in the lowest quartile had a 3.72-fold higher risk than those in the highest quartile. Even after adjusting for potential confounding factors, this association was found to be significant. Low serum adiponectin levels were found to be independently associated with a higher risk for the development of hypertension. Our results therefore suggest that hypoadiponectinemia is a novel predictor of hypertension.
Imatoh et al. (Tue,) conducted a cohort in Healthy men (at risk for hypertension) (n=391). Low serum adiponectin levels (<4.5 μg/mL) vs. High serum adiponectin levels (>8.5 μg/mL) was evaluated on Development of hypertension (OR 3.72, 95% CI 1.41-9.84). Men in the lowest quartile of serum adiponectin had a 3.72-fold higher risk of developing new-onset hypertension compared to those in the highest quartile.