Key points are not available for this paper at this time.
In recent years, the connection between chromatin structure and its transcriptional activity has attracted considerable experimental effort. The post‐translational modifications to both the core histones and the linker histones are finely tuned through interactions with transcriptional regulators and change chromatin structure in a way to allow transcription to occur. Here we review evidence for the involvement of linker histones in transcriptional regulation and suggest a scenario in which the reversible and controllable binding/displacement of proteins of this class to the nucleosome entry/exit point determine the accessibility of the nucleosomal DNA to the transcriptional machinery.—Zlatanova, J., Caiafa, P., van Holde, K. Linker histone binding and displacement: versatile mechanism for transcriptional regulation. FASEB J. 14, 1697–1704 (2000)
Zlatanova et al. (Fri,) studied this question.