Strategies designed to reverse the effects of neurohormones on the kidney in congestive heart failure have so far had limited success.
Neurohormonal activation in heart failure leads to sodium and water retention, and strategies to reverse these renal effects have had limited success.
The syndrome of congestive heart failure is characterized by activation of many neurohormonal systems with vasoconstrictor and vasodilator actions. Data suggest that the stimulus that evokes this response is a threat to the arterial blood pressure. The long-term consequences of this response on the kidney are retention of sodium and water. Strategies designed to reverse the effects of these neurohormones on the kidney have so far had limited success.
Anand et al. (Thu,) conducted a review in Congestive heart failure with renal dysfunction. Strategies to reverse neurohormonal effects was evaluated. Strategies designed to reverse the effects of neurohormones on the kidney in congestive heart failure have so far had limited success.