Neurohormonal activation in heart failure leads to sodium and water retention, and strategies to reverse these renal effects have had limited success.
Clinicians should prioritize proven HF therapies amid limited renal neurohormonal reversal success; leaves open need for novel targeted strategies in trials.
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Anand et al. (1997) conducted a review in Congestive heart failure with renal dysfunction. Strategies to reverse neurohormonal effects was evaluated.
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