Neurohormonal activation in heart failure leads to sodium and water retention, and strategies to reverse these renal effects have had limited success.
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Clinicians should prioritize proven HF therapies amid limited renal neurohormonal reversal success; leaves open need for novel targeted strategies in trials.
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Anand et al. (1997) conducted a review in Congestive heart failure with renal dysfunction. Strategies to reverse neurohormonal effects was evaluated.
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