Fibrinogen promotes cardiomyocyte hypertrophy via the TLR4/MyD88/NF-κB signaling pathway, providing mechanistic insight into cardiac remodeling.
Our results suggest that fibrinogen induces hypertrophic response of cardiomyocytes partially through a TLR4-mediated, MyD88-dependent NF-kappaB pathway.
Li et al. (Fri,) studied this question.