Fibrinogen promotes cardiomyocyte hypertrophy via the TLR4/MyD88/NF-κB signaling pathway, providing mechanistic insight into cardiac remodeling.
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Hypothesis-generating for fibrinogen in cardiomyocyte hypertrophy; leaves open relevance to human cardiac remodeling.
Our results suggest that fibrinogen induces hypertrophic response of cardiomyocytes partially through a TLR4-mediated, MyD88-dependent NF-kappaB pathway.
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Li et al. (2009) studied this question.
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