Admission hypertriglyceridemia in patients with severe acute pancreatitis was associated with higher mortality (13.1% vs 9.1%, P<0.01) and increased rates of renal failure, shock, and infection.
Cohort (n=176)
Does admission hypertriglyceridemia worsen outcomes in patients with severe acute pancreatitis?
Admission hypertriglyceridemia is associated with more severe disease, higher complication rates, and increased mortality in patients with severe acute pancreatitis.
Absolute Event Rate: 13.1% vs 9.1%
p-value: p=<0.01
AIM: To investigate the effect of admission hypertriglyceridemia (HTG) on the episodes of severe acute pancreatitis (SAP). METHODS: One hundred and seventy-six patients with SAP were divided into HTG group (n = 45) and control group (n = 131) according to admission triglyceride (TG) > or = 5.65 mmol/L and < 5.65 mmol/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson' s score, acute physiology and chronic heath evaluation II (APACHE II) score, Balthazar's computed tomography (CT) score, complications and mortality were compared. Correlation between admission TG and 24-h APACHE II score was analyzed. RESULTS: SAP patients with HTG were younger (40.8 +/- 9.3 years vs 52.6 +/- 13.4 years, P < 0.05) with higher etiology rate of overeating, high-fat diet (40.0% vs 14.5%, P < 0.05) and alcohol abuse (46.7% vs 23.7%, P < 0.01), incidence rate of hypocalcemia (86.7% vs 63.4%, P < 0.01) and hypoalbuminemia (84.4% vs 60.3%, P < 0.01), 24-h APACHE II score (13.6 +/- 5.7 vs 10.7 +/- 4.6, P < 0.01) and admission serum glucose (17.7 +/- 7.7 vs 13.4 +/- 6.1, P < 0.01), complication rate of renal failure (51.1% vs 16.8%, P < 0.01), shock (37.9% vs 14.5%, P < 0.01) and infection (37.4% vs 18.3%, P < 0.01) and mortality (13.1% vs 9.1%, P < 0.01). Logistic regression analysis showed a positive correlation between admission TG and 24-h APACHE II score (r = 0 .509, P = 0.004). CONCLUSION: The clinical features of SAP patients with HTG are largely consistent with previous studies. HTG aggravates the episodes of SAP.
Deng et al. (Tue,) conducted a cohort in Severe acute pancreatitis (n=176). Admission hypertriglyceridemia (TG ≥ 5.65 mmol/L) vs. Admission TG < 5.65 mmol/L was evaluated on Mortality (p=<0.01). Admission hypertriglyceridemia in patients with severe acute pancreatitis was associated with higher mortality (13.1% vs 9.1%, P<0.01) and increased rates of renal failure, shock, and infection.