Key result
Admission hypertriglyceridemia in patients with severe acute pancreatitis was associated with higher mortality (13.1% vs 9.1%, P<0.01) and increased rates of renal failure, shock, and infection.
Why the study?
Does admission hypertriglyceridemia worsen outcomes in patients with severe acute pancreatitis?
Cohort (n=176)
Does admission hypertriglyceridemia worsen outcomes in patients with severe acute pancreatitis?
Absolute Event Rate: 13.1% vs 9.1%
p-value: p=<0.01
Admission hypertriglyceridemia is associated with more severe disease, higher complication rates, and increased mortality in patients with severe acute pancreatitis.
Admission HTG signals greater early severity in SAP; leaves open whether it drives outcomes or warrants specific intervention.
AIM: To investigate the effect of admission hypertriglyceridemia (HTG) on the episodes of severe acute pancreatitis (SAP). METHODS: One hundred and seventy-six patients with SAP were divided into HTG group (n = 45) and control group (n = 131) according to admission triglyceride (TG) > or = 5.65 mmol/L and < 5.65 mmol/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson' s score, acute physiology and chronic heath evaluation II (APACHE II) score, Balthazar's computed tomography (CT) score, complications and mortality were compared. Correlation between admission TG and 24-h APACHE II score was analyzed. RESULTS: SAP patients with HTG were younger (40.8 +/- 9.3 years vs 52.6 +/- 13.4 years, P < 0.05) with higher etiology rate of overeating, high-fat diet (40.0% vs 14.5%, P < 0.05) and alcohol abuse (46.7% vs 23.7%, P < 0.01), incidence rate of hypocalcemia (86.7% vs 63.4%, P < 0.01) and hypoalbuminemia (84.4% vs 60.3%, P < 0.01), 24-h APACHE II score (13.6 +/- 5.7 vs 10.7 +/- 4.6, P < 0.01) and admission serum glucose (17.7 +/- 7.7 vs 13.4 +/- 6.1, P < 0.01), complication rate of renal failure (51.1% vs 16.8%, P < 0.01), shock (37.9% vs 14.5%, P < 0.01) and infection (37.4% vs 18.3%, P < 0.01) and mortality (13.1% vs 9.1%, P < 0.01). Logistic regression analysis showed a positive correlation between admission TG and 24-h APACHE II score (r = 0 .509, P = 0.004). CONCLUSION: The clinical features of SAP patients with HTG are largely consistent with previous studies. HTG aggravates the episodes of SAP.
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Deng et al. (2008) conducted a cohort in Severe acute pancreatitis (n=176). Admission hypertriglyceridemia (TG ≥ 5.65 mmol/L) vs. Admission TG < 5.65 mmol/L was evaluated on Mortality (p=<0.01). Admission hypertriglyceridemia in patients with severe acute pancreatitis was associated with higher mortality (13.1% vs 9.1%, P<0.01) and increased rates of renal failure, shock, and infection.
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