January 1, 1986Open Access
Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig
Key Result
Infusion of Iloprost enhanced the recovery of regional myocardial function to 40% of baseline during the first two hours of reperfusion after coronary artery occlusion in pigs.
Structured PICO
Does Iloprost improve recovery of regional myocardial function after coronary artery occlusion and reperfusion in a pig model?
P
Population
28 young Yorkshire pigs (22-30 kg) subjected to 20 min left anterior descending coronary artery occlusion followed by 2 hours of reperfusion.
I
Intervention
Iloprost 100 ng kg-1 min-1 infused intravenously starting 10 min before occlusion and continuing throughout the experiment.
C
Comparator
Solvent (vehicle) infusion.
O
Outcome
Recovery of regional myocardial function (systolic wall thickening) during the first two hours of reperfusion.surrogate
Iloprost enhances the recovery of regional myocardial function after ischemia and reperfusion in a porcine model, independent of myocardial oxygen demand or ATP recovery.
Abstract
Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content.