Key result
Infusion of Iloprost enhanced the recovery of regional myocardial function to 40% of baseline during the first two hours of reperfusion after coronary artery occlusion in pigs.
Why the study?
Does Iloprost improve recovery of regional myocardial function after coronary artery occlusion and reperfusion in a pig model?
Does Iloprost improve recovery of regional myocardial function after coronary artery occlusion and reperfusion in a pig model?
Iloprost enhances the recovery of regional myocardial function after ischemia and reperfusion in a porcine model, independent of myocardial oxygen demand or ATP recovery.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for iloprost in porcine reperfusion injury; leaves open translation to human myocardial infarction.
Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content.
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Giessen et al. (1986) studied Coronary artery occlusion and myocardial reperfusion injury. Iloprost (ZK 36374) was evaluated on Recovery of regional myocardial function. Infusion of Iloprost enhanced the recovery of regional myocardial function to 40% of baseline during the first two hours of reperfusion after coronary artery occlusion in pigs.
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