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It was with pride that I accepted the honour of giving the Thomas Lewis Lecture for 1977 and I have chosen to present a subject to which we have devoted our main research efforts during the past 10 years. This Memorial Lecture seems to me an appropriate occasion to present our findings, because they represent the fruit of investigations performed in the scientific spirit of Sir Thomas and because they bring objective support to an hypothesis that he had brilliantly anticipated over 40 years ago,' on the basis of acute clinical observa- tions and of logical deductions.
A Maseri (Sun,) studied this question.
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