Are home blood pressure measurements reproducible and subject to a placebo effect when assessing antihypertensive treatments?
Subjects in a trial assessing antihypertensive drug effects
Home blood pressure (HBP) measurements
Placebo
Reproducibility of HBP measurement and magnitude of placebo effectsurrogate
Home blood pressure measurement is highly reproducible and exhibits minimal placebo effect, allowing for smaller sample sizes in trials assessing antihypertensive efficacy.
The results suggest that the HBP measurement is highly reproducible and that there is a minimal, if any, placebo effect. These characteristics of HBP contribute to minimizing the number of subjects necessary for assessment of antihypertensive drug effects in comparative studies between an active treatment and placebo.
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Imai et al. (Thu,) studied this question.
synapsesocial.com/papers/69d575ccc928a9acfd89a239 — DOI: https://doi.org/10.1097/00004872-200102000-00003
Yutaka Imai
Tohoku University
Takayoshi Ohkubo
Preventive Cardiology
Atsushi Hozawa
Preventive Cardiology
Journal of Hypertension
Tohoku University
Faculty of Public Health
Miwa Hospital
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