In a canine model of tachycardia-induced heart failure, cellular remodeling leads to decreased density of T-tubules and L-type Ca2+ channels, contributing to abnormal excitation-contraction coupling.
Cellular remodeling in heart failure results in decreased density of T-tubules and L-type Ca(2+) channels, which contribute to abnormal EC coupling.
Jia‐Qiang He (Thu,) studied this question.