In a canine model of tachycardia-induced heart failure, cellular remodeling leads to decreased density of T-tubules and L-type Ca2+ channels, contributing to abnormal excitation-contraction coupling.
Supports investigation of T-tubule restoration as a therapeutic target in HF; leaves open translation from canine models to humans.
Cellular remodeling in heart failure results in decreased density of T-tubules and L-type Ca(2+) channels, which contribute to abnormal EC coupling.
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Jia‐Qiang He (2001) studied this question.
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