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February 1, 2001Cardiovascular Research299 citationsOpen Access

Reduction in density of transverse tubules and L-type Ca2+ channels in canine tachycardia-induced heart failure

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JHJia‐Qiang He

Key Points

  • To investigate cellular remodeling affecting transverse tubules and L-type calcium channel density in a canine model of tachycardia-induced heart failure.
  • Evaluated cardiac cellular structures in a canine model of tachycardia-induced heart failure.

Structured PICO

P
Population
Canine tachycardia-induced heart failure model
O
Outcome
Density of transverse tubules and L-type Ca2+ channelssurrogate

In a canine model of tachycardia-induced heart failure, cellular remodeling leads to decreased density of T-tubules and L-type Ca2+ channels, contributing to abnormal excitation-contraction coupling.

Abstract

Cellular remodeling in heart failure results in decreased density of T-tubules and L-type Ca(2+) channels, which contribute to abnormal EC coupling.

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Cite This Study

Jia‐Qiang He (2001) studied this question.

synapsesocial.com/papers/69d56ecc75589c71d767d67chttps://doi.org/10.1016/s0008-6363(00)00256-x
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