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Before the twentieth century, it was not possible to describe the essentials of a diet that could support life, growth and reproduction of higher animals. The discovery of vitamin A by McCollum and Davis in 1913 ushered in the era of accessory food substances culminating in the achievement of that goal. It included the discovery of vitamin D and its production in skin caused by ultraviolet light. This was followed by a description of its actions at the physiological level that resulted in a healthy skeleton and beyond. To carry out these functions, vitamin D is converted to a hormone that acts through a nuclear receptor. The findings leading to this concept and their importance to biology and medicine are presented.
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Hector F. DeLuca
BoneKEy Reports
University of Wisconsin–Madison
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Hector F. DeLuca (Wed,) studied this question.
www.synapsesocial.com/papers/69d994d18d5c517421a3bf9b — DOI: https://doi.org/10.1038/bonekey.2013.213