Obese diabetics with autonomic neuropathy had a significantly higher apnea-hypopnea index compared to those without neuropathy (39.5 vs 15.8, p<0.01).
Cross-Sectional (n=28)
Does the presence of diabetic autonomic neuropathy increase the risk and severity of obstructive sleep apnea-hypopnea in obese diabetics?
The presence of diabetic autonomic neuropathy in obese diabetic patients is associated with a significantly higher frequency and severity of obstructive sleep apnea-hypopnea.
Absolute Event Rate: 39.5% vs 15.8%
p-value: p=<0.01
BACKGROUND: Nonobese diabetics with diabetic autonomic neuropathy (DAN) show an elevated prevalence of obstructive sleep apnea-hypopnea (OSAH). OBJECTIVE: It was the aim of this study to assess if the presence of DAN could further increase the risk of developing OSAH in obese diabetics. METHODS: Eighteen obese diabetic patients, 8 with DAN age 57 +/- 5 years, body mass index (BMI) 35 +/- 4 and 10 without DAN (age 56 +/- 8 years, BMI 37 +/- 5), were recruited. Ten age-matched obese subjects were studied as controls (age 53 +/- 12 years, BMI 34 +/- 3). All subjects underwent a cardiorespiratory sleep study in the in-hospital sleep laboratory to obtain the apnea-hypopnea index (AHI) and oxygen desaturation indices. RESULTS: Diabetics with DAN (Ob-DAN+) had a higher AHI than diabetics without DAN (Ob-DAN-) and controls, amounting to 39.5 +/- 13 versus 15.8 +/- 12 (p or = 15) occurred in all Ob-DAN+ and only in 4 Ob-DAN- and 4 control patients. Moreover, the indices reflecting the impairment of oxygen saturation (SaO(2)) during sleep such as the mean lowest SaO(2) and sleep time with a SaO(2) <90% were more severely affected in Ob-DAN+ patients compared with the other groups and were associated with longer obstructive respiratory events. CONCLUSIONS: Apneas-hypopneas are more frequent and last longer in Ob-DAN+ than in other obese subjects, with or without diabetes.
Bottini et al. (Wed,) conducted a cross-sectional in Obstructive sleep apnea in obese diabetics (n=28). Diabetic autonomic neuropathy vs. Obese diabetics without autonomic neuropathy and obese controls was evaluated on Apnea-hypopnea index (AHI) (p=<0.01). Obese diabetics with autonomic neuropathy had a significantly higher apnea-hypopnea index compared to those without neuropathy (39.5 vs 15.8, p<0.01).