Symptomatic Patterns, Biologic Behavior, and Prognosis in Cancer of the Lung

Article1 July 1964Symptomatic Patterns, Biologic Behavior, and Prognosis in Cancer of the LungPractical Application of Boolean Algebra and Clinical TaxonomyALVAN R. FEINSTEIN, M.D.ALVAN R. FEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-1-27 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhysicians generally believe that human cancer is most curable when found early and excised completely. In this concept, a tumor is found "early" if confined to its primary site without regional or distant dissemination, and is "excised completely" if surgically removed together with an appropriate margin of normal tissue. Results of treatment for cancer confirm the concept consistently, and show survival rates that are best in patients with resectable tumors, and worst in those with lesions discovered too "late" to be removed.This rule of surgical therapy is regularly violated by exceptions. Some patients who come to treatment promptly after...References1. MACDONALD I: Biological predeterminism in human cancer. Surg. Gynec. Obstet. 92: 443, 1951. MedlineGoogle Scholar2. FEINSTEINZACALASPAGNUOLO ARJGM: The pattern of symptoms, pretreatment interval, and prognosis of acute rheumatic fever. Ann. Intern. Med. 57: 563, 1962. LinkGoogle Scholar3. FEINSTEINSPAGNUOLO ARM: The clinical patterns of acute rheumatic fever: a reappraisal. Medicine 41: 279, 1962. CrossrefMedlineGoogle Scholar4. FEINSTEIN AR: Boolean algebra and clinical taxonomy. I. Analytic synthesis of the general spectrum of human disease. New Eng. J. Med. 269: 929, 1963. CrossrefMedlineGoogle Scholar5. 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COLE WH: The relationship between duration of symptoms and results of treatment in cancer patients. Surgery 51: 819, 1962. MedlineGoogle Scholar19. GARLANDCOULSONWOLLIN LHWE: The rate of growth and apparent duration of untreated primary bronchial carcinoma. Cancer 16: 694, 1963. CrossrefMedlineGoogle Scholar20. SUTHERLAND R: Cancer. The Significance of Delay. Butterworth the Yale Fluid Research Fund; and the National Cancer Institute (grant CA 07155-01).Requests for reprints should be addressed to Alvan R. Feinstein, M. D., Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLung CancerClinical and Organizational Factors in the Initial Evaluation of Patients With Lung CancerHow Have We Diagnosed Early-Stage Lung Cancer without Radiographic Screening? 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FEINSTEIN, M.D. 1 July 1964Volume 61, Issue 1 Page: 27-43 Keywords Behavior Biologics Cancer treatment Hospital medicine Inflammation Lesions Lung and intrathoracic tumors Research funding Surgical pathology ePublished: 1 December 2008 Issue Published: 1 July 1964 PDF downloadLoading ...