Is fibrinolytic activity altered in men who sustained an acute myocardial infarction before age 60 compared to healthy controls?
Fibrinolytic activity may be reduced in young men with a history of early myocardial infarction and elevated diastolic blood pressure.
Fibrinolytic activity in plasma after venous occlusion was determined on two consecutive days 1-5 years after an acute myocardial infarction sustained before the age of 60 years in a group of 66 non-diabetic men with normal serum cholesterol levels, and in an age- and sex-matched reference group of 32 men. The infarction group was divided into 2 subgroups: one with normal (n = 42), the other with elevated (n = 24) diastolic blood pressure. Variance analysis did not reveal any statistically significant differences in fibrinolytic activity after repeated provocation between the three groups, but in a Student's test the value was significantly lower in the infarction group with high diastolic pressure than in the reference group. A relationship was found between apolipoprotein AI and fibrinolytic activity after repeated provocation.
Franzén et al. (Wed,) studied this question.