Why the study?
Is fibrinolytic activity altered in men who sustained an acute myocardial infarction before age 60 compared to healthy controls?
Is fibrinolytic activity altered in men who sustained an acute myocardial infarction before age 60 compared to healthy controls?
Fibrinolytic activity may be reduced in young men with a history of early myocardial infarction and elevated diastolic blood pressure.
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Reduced fibrinolytic activity associated with early MI plus high diastolic pressure; leaves open causal role and clinical relevance.
Fibrinolytic activity in plasma after venous occlusion was determined on two consecutive days 1-5 years after an acute myocardial infarction sustained before the age of 60 years in a group of 66 non-diabetic men with normal serum cholesterol levels, and in an age- and sex-matched reference group of 32 men. The infarction group was divided into 2 subgroups: one with normal (n = 42), the other with elevated (n = 24) diastolic blood pressure. Variance analysis did not reveal any statistically significant differences in fibrinolytic activity after repeated provocation between the three groups, but in a Student's test the value was significantly lower in the infarction group with high diastolic pressure than in the reference group. A relationship was found between apolipoprotein AI and fibrinolytic activity after repeated provocation.
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Franzén et al. (1983) studied this question.
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