Key result
Acute MI in men is linked to ~61% lower bio-available testosterone levels versus controls.
Why the study?
The effect of acute myocardial infarction on plasma levels of bio-available testosterone in men and its association with fibrinolytic factors was unclear.
Comparison
Patients with acute myocardial infarction vs control subjects with non-specific chest pain
Design
Prospective case-control study
Follow-up
Throughout admission
Authors
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Acute MI links to lower testosterone and pro-thrombotic profile in men; hypothesis-generating, should not yet change practice.
Case-Control (n=30)
Absolute Event Rate: 2.07% vs 5.3%
p-value: p=< 0.05
Total and bio-available testosterone levels fall acutely following myocardial infarction in men, which is associated with an adverse, pro-thrombotic fibrinolytic profile.
Pugh et al. (2002) conducted a case-control in Acute myocardial infarction (n=30). Acute myocardial infarction vs. Non-specific chest pain (controls) was evaluated on Bio-available testosterone levels (nmol/L) (p=< 0.05). Acute myocardial infarction in men was associated with significantly lower levels of bio-available testosterone compared to controls (2.07 vs 5.3 nmol/L, p<0.05).
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