February 16, 2012
View Full PaperImpact of lower achieved blood pressure on outcomes in hypertensive patients
Structured PICO
Does achieving an SBP of 130 mmHg or less reduce cardiovascular risk or mortality compared to an SBP of 131 to 141 mmHg in hypertensive patients?
P
Population
Hypertensive patients
I
Intervention
Achieved systolic blood pressure (SBP) 130 mmHg or less
C
Comparator
Achieved systolic blood pressure (SBP) of 131 to 141 mmHg
O
Outcome
Cardiovascular risk, risk of death, and cardiovascular mortalityhard clinical
Achieving a lower SBP (≤130 mmHg) in hypertensive patients may be associated with increased mortality compared to moderate control (131-141 mmHg), highlighting the need for randomized trials on aggressive targets.
Abstract
Achieved SBP 130 mmHg or less is not associated with lower cardiovascular risk than SBP of 131 to 141 mmHg and is associated with a significantly increased risk of death and trend towards increased cardiovascular mortality. These findings support the need for randomized evaluation of treatment to more aggressive vs. conventional SBP targets.