The mechanism of action of nitroglycerin in alleviating angina pectoris remains unknown, with possibilities including increased oxygen supply or reduced energy expenditure.
Though the nitrate drugs have been widely used to alleviate or prevent angina pectoris for nearly 100 years, the mechanism of their action remains unknown. The two possibilities that have been most widely considered are (a) that they cause an increase in oxygen supply to the heart through coronary vasodilatation and increase in coronary flow, and (b) that they cause a reduction in energy expenditure of the ventricular muscle.
Hoeschen et al. (Tue,) conducted a other in angina pectoris. nitroglycerin was evaluated. The mechanism of action of nitroglycerin in alleviating angina pectoris remains unknown, with possibilities including increased oxygen supply or reduced energy expenditure.
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