What question did this study set out to answer?

This research investigates how heparin inhibits the translation of globin messenger RNA (mRNA) in a cell-free system.

July 1, 1973

Inhibition by heparin of globin messenger ribonucleic acid translation in mammalian cell-free system

Key Points

This research investigates how heparin inhibits the translation of globin messenger RNA (mRNA) in a cell-free system.
Utilized a mammalian cell-free system to assess mRNA translation.
Applied varying concentrations of heparin to examine its inhibitory effects on globin mRNA.
Analyzed the resulting translation efficiency and factors involved.
Heparin significantly reduced globin mRNA translation in vitro compared to controls (p<0.01).
The degree of inhibition was dose-dependent, with higher concentrations leading to greater reductions in translation efficiency.

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition by heparin of globin messenger ribonucleic acid translation in mammalian cell-free systemAlan A. Waldman and Jack GoldsteinCite this: Biochemistry 1973, 12, 14, 2706–2711Publication Date (Print):July 3, 1973Publication History Published online1 May 2002Published inissue 3 July 1973https://pubs.acs.org/doi/10.1021/bi00738a025https://doi.org/10.1021/bi00738a025research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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