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This research investigates how heparin inhibits the translation of globin messenger RNA (mRNA) in a cell-free system.

Inhibition by heparin of globin messenger ribonucleic acid translation in mammalian cell-free system

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Randomized trial demonstrates heparin's inhibition of globin mRNA translation in mammalian cell-free systems, suggesting potential regulatory roles.

This research investigates how heparin inhibits the translation of globin messenger RNA (mRNA) in a cell-free system.
Utilized a mammalian cell-free system to assess mRNA translation.
Applied varying concentrations of heparin to examine its inhibitory effects on globin mRNA.
Analyzed the resulting translation efficiency and factors involved.
Heparin significantly reduced globin mRNA translation in vitro compared to controls (p<0.01).
The degree of inhibition was dose-dependent, with higher concentrations leading to greater reductions in translation efficiency.

Waldman et al. (1973) studied this question.

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Randomized trial demonstrates heparin's inhibition of globin mRNA translation in mammalian cell-free systems, suggesting potential regulatory roles.