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February 15, 1972Biochemistry

Isolation of mammalian messenger ribonucleic acid

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Authors

GBGeorge BrawermanBoston UniversityJMJózef MendeckiTufts UniversitySLSe Yong LeeSoongsil University

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Overview

Laboratory investigation demonstrates an extraction method for messenger ribonucleic acid in mammalian tissues, indicating a pathway to study protein synthesis.

Key Points

  • To establish a biochemical method for isolating and purifying functional messenger ribonucleic acid from mammalian cellular sources.
  • Biochemical extraction and fractionation procedures were applied to isolate ribonucleic acid fractions from mammalian cells.
  • A reproducible protocol was developed that yields intact messenger ribonucleic acid separated from other cellular RNA species.
  • The isolated ribonucleic acid fractions retain molecular integrity suitable for functional and translational characterization.

Cite This Study

Brawerman et al. (1972) studied this question.

synapsesocial.com/papers/6a09782c16dfdfe7ed341eb8https://doi.org/10.1021/bi00754a027
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