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In this murine model, inhibiting gut epithelial apoptosis by overexpression of Bcl-2 was associated with a survival advantage in P aeruginosa pneumonia-induced sepsis. These results suggest that intestinal epithelial apoptosis may play a role in sepsis-related mortality.
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Craig M. Coopersmith (Wed,) studied this question.
www.synapsesocial.com/papers/69d8396e8c03fbaff8bee340 — DOI: https://doi.org/10.1001/jama.287.13.1716
Craig M. Coopersmith
JAMA
Washington University in St. Louis
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