Animal study demonstrates improved survival following Bcl-2-mediated gut apoptosis inhibition in murine pneumonia sepsis, indicating intestinal cell death drives mortality.
In this murine model, inhibiting gut epithelial apoptosis by overexpression of Bcl-2 was associated with a survival advantage in P aeruginosa pneumonia-induced sepsis. These results suggest that intestinal epithelial apoptosis may play a role in sepsis-related mortality.
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Craig M. Coopersmith (2002) studied this question.
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