Key result
T-cell PPARγ inhibition improves survival and halts T-cell depletion during polymicrobial sepsis in mice.
Why the study?
Does PPARγ inhibition in T cells improve survival and prevent T-cell apoptosis in mice with polymicrobial sepsis?
Does PPARγ inhibition in T cells improve survival and prevent T-cell apoptosis in mice with polymicrobial sepsis?
Inhibition of PPARγ in T cells prevents T-cell apoptosis and improves survival in murine models of polymicrobial sepsis.
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Warrants caution against clinical translation; leaves open whether PPARγ inhibition improves human sepsis outcomes.
Paulus et al. (2011) studied Polymicrobial sepsis. PPARγ inhibition (GW9662 or Tc-PPARγ(-/-)) was evaluated on Survival and T-cell depletion. PPARγ inhibition in T cells provided a survival advantage and abrogated T-cell depletion during polymicrobial sepsis in mice.
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