Key result
Ppara null mice had dramatically reduced 7-day survival compared with wild-type mice in experimental polymicrobial sepsis (3% vs 63%; p < 0.0001), irrespective of bone marrow Ppara status.
Why the study?
Does nonhematopoietic PPAR-α expression improve survival and protect against cardiac injury in a mouse model of polymicrobial sepsis?
RCT
Randomized
Does nonhematopoietic PPAR-α expression improve survival and protect against cardiac injury in a mouse model of polymicrobial sepsis?
Absolute Event Rate: 3% vs 63%
p-value: p=< 0.0001
Nonhematopoietic PPAR-α expression plays a critical role in survival during experimental polymicrobial sepsis, likely by preventing cardiac injury from inadequate fatty acid oxidation.
Nonhematopoietic PPAR-α may protect against sepsis-induced cardiac injury in mice; hypothesis-generating for human translation.
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Standage et al. (2016) conducted an RCT in Experimental Polymicrobial Sepsis. Ppara null mutation vs. Wild-type mice was evaluated on Survival at 7 days (p=< 0.0001). Ppara null mice had dramatically reduced 7-day survival compared with wild-type mice in experimental polymicrobial sepsis (3% vs 63%; p < 0.0001), irrespective of bone marrow Ppara status.
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