October 2, 2013ShockOpen Access

Conditional Deletion of Cardiomyocyte Peroxisome Proliferator-Activated Receptor γ Enhances Myocardial Ischemia-Reperfusion Injury in Mice

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Why the study?

Does conditional deletion of cardiomyocyte PPARγ enhance myocardial ischemia-reperfusion injury in mice?

Population

Mice with α-myosin heavy chain-restricted Cre-mediated PPARγ deficiency

Comparison

Tamoxifen treatment for 4 days to induce PPARγ… vs Oil diluent vehicle treatment, followed by…

Design

Preclinical

Follow-up

2 hours (reperfusion phase)

Authors

MHMichael J. HobsonIndiana University Health PHPaul W. HakeCincinnati Children's Hospital Medical Center MOMichael O′ConnorUniversity College London Hospitals NHS Foundation Trust

Discussion

Member takes

Implication

Supports PPARγ cardioprotection in murine ischemia-reperfusion injury; hypothesis-generating for human translation.

Structured PICO

Does conditional deletion of cardiomyocyte PPARγ enhance myocardial ischemia-reperfusion injury in mice?

Population

Mice with α-myosin heavy chain-restricted Cre-mediated PPARγ deficiency

Intervention

Tamoxifen treatment (30 mg/kg intraperitoneally) for 4 days to induce PPARγ deficiency, followed by 30-min ligation of the left anterior descending coronary artery and 2-h reperfusion

Comparator

Oil diluent vehicle treatment, followed by 30-min ligation of the left anterior descending coronary artery and 2-h reperfusion

Outcome

Myocardial damage (assessed by tissue activity of myeloperoxidase, plasma levels of troponin I, echocardiographic ventricular dilatation and systolic dysfunction, and plasma cytokines)surrogate

Cardiomyocyte-specific deletion of PPARγ exacerbates myocardial ischemia-reperfusion injury, highlighting its protective role against inflammation.

Cite This Study

Hobson et al. (2013) studied this question.

synapsesocial.com/papers/6a7628d41078cf7de2b25d90 https://doi.org/10.1097/shk.0000000000000051

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Conditional Deletion of Cardiomyocyte Peroxisome Proliferator-Activated Receptor γ Enhances Myocardial Ischemia-Reperfusion Injury in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Conditional Deletion of Cardiomyocyte Peroxisome Proliferator-Activated Receptor γ Enhances Myocardial Ischemia-Reperfusion Injury in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider