Key result
The PPAR-α agonist GW7647 reduced infarct size by 28% and 35% at doses of 1 and 3 mg/kg/day, respectively, in a mouse model of ischemia/reperfusion injury (P < 0.01).
Why the study?
Does GW7647 reduce infarct size in male mice subjected to myocardial ischemia/reperfusion injury?
Population
Male mice subjected to 30 minutes of left anterior descending coronary artery occlusion
Comparison
GW7647 administered orally for 2 days, with a… vs Vehicle
Design
Preclinical
Follow-up
24 hours
Authors
Loading...
GW7647 attenuates murine infarct size; extends preclinical PPAR-α data but leaves open clinical translation.
Does GW7647 reduce infarct size in male mice subjected to myocardial ischemia/reperfusion injury?
Activation of PPAR-α with GW7647 protects the heart from ischemia/reperfusion injury through metabolic and anti-inflammatory mechanisms in a mouse model.
Yue et al. (2003) studied this question. The PPAR-α agonist GW7647 reduced infarct size by 28% and 35% at doses of 1 and 3 mg/kg/day, respectively, in a mouse model of ischemia/reperfusion injury (P < 0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: