Electrochemical Carboxylation of α,α-Difluorotoluene Derivatives and Its Application to the Synthesis of α-Fluorinated Nonsteroidal Anti-Inflammatory Drugs

Electrochemical carboxylation of α,α-difluorotoluene derivatives resulted in an efficient fixation of carbon dioxide to give the corresponding α-fluorophenylacetic acids in good yields, and this reaction was successfully applied to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs (NSAIDs).