Low serum total cholesterol was associated with low mood and a heightened risk of hospital treatment for major depressive disorder and death from suicide.
Cohort (n=29,133)
Does low serum total cholesterol increase the risk of major depression and suicide in men aged 50-69 years?
Low serum total cholesterol in middle-aged men is associated with an increased risk of low mood, major depressive disorder, and suicide.
BACKGROUND: It has been suggested that low serum total cholesterol is associated with an increased risk of suicide. AIMS: To study the association between serum total cholesterol, depression and suicide using versatile, prospective data. METHOD: A total of 29,133 men aged 50-69 years were followed up for 5-8 years. Baseline blood samples were analysed for serum total and high-density lipoprotein cholesterol concentrations. Self-reported depression was recorded, data on hospital treatments due to depressive disorders were derived from the National Hospital Discharge Register and deaths from suicide were identified from death certificates. RESULTS: Low serum total cholesterol was associated with low mood and subsequently a heightened risk of hospital treatment due to major depressive disorder and of death from suicide. CONCLUSIONS: Our results suggest that low serum total cholesterol appears to be associated with low mood and thus to predict its serious consequences.
Partonen et al. (Wed,) conducted a cohort in Major depression and suicide (n=29,133). Low serum total cholesterol was evaluated on Low mood, hospital treatment due to major depressive disorder, and death from suicide. Low serum total cholesterol was associated with low mood and a heightened risk of hospital treatment for major depressive disorder and death from suicide.
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