September 1, 1999The British Journal of Psychiatry
Association of low serum total cholesterol with major depression and suicide
Key result
Low serum total cholesterol was associated with low mood and a heightened risk of hospital treatment for major depressive disorder and death from suicide.
Why the study?
Does low serum total cholesterol increase the risk of major depression and suicide in men aged 50-69 years?
Population
29,133 men aged 50-69 years
Comparison
Low serum total cholesterol vs Higher serum total cholesterol (implied)
Design
Cohort
Follow-up
5-8 years
Authors
Discussion
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Implication
May prompt mood screening in middle-aged men with low cholesterol; hypothesis-generating and requires prospective validation.
Study Design
Type
Cohort (n=29,133)
Structured PICO
Does low serum total cholesterol increase the risk of major depression and suicide in men aged 50-69 years?
P
Population
29,133 men aged 50-69 years
I
Intervention
Low serum total cholesterol
C
Comparator
Higher serum total cholesterol (implied)
O
Outcome
Self-reported depression, hospital treatments due to depressive disorders, and deaths from suicidehard clinical
Low serum total cholesterol in middle-aged men is associated with an increased risk of low mood, major depressive disorder, and suicide.
Cite This Study
Partonen et al. (1999) conducted a cohort in Major depression and suicide (n=29,133). Low serum total cholesterol was evaluated on Low mood, hospital treatment due to major depressive disorder, and death from suicide. Low serum total cholesterol was associated with low mood and a heightened risk of hospital treatment for major depressive disorder and death from suicide.