The TT genotype of the C-344T CYP11B2 polymorphism was associated with 14% higher plasma aldosterone, 3.7 mmHg higher systolic, and 2.1 mmHg higher diastolic blood pressure compared to CC (P<0.05).
Cross-Sectional (n=1,313)
Is the C-344T CYP11B2 polymorphism associated with differences in plasma aldosterone, renin activity, and blood pressure in a multi-ethnic population?
The C-344T CYP11B2 polymorphism is associated with higher blood pressure, plasma aldosterone levels, and aldosterone-to-renin ratio, independent of ethnicity.
Effect estimate: 14% higher aldosterone, 3.7 mmHg higher SBP, 2.1 mmHg higher DBP
p-value: p=< 0.05
BACKGROUND: The aldosterone synthase gene (CYP1B2) locus is a candidate region involved in the development of hypertension. OBJECTIVE: To study the relationship between the C-344T CYP1B2 polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population. DESIGN: Population-based, cross-sectional study of 1313 middle-aged men and women (456 white, 441 of African origin and 416 South Asian). Anthropometry, blood pressure, biochemistry, questionnaire data and timed urine collections were taken with standardized techniques. All were genotyped for the C-344T CYP11B2 polymorphism. RESULTS: The frequency of the C allele was significantly lower in people of African origin (0.21) than in white (0.46) and South Asian (0.43) (P /= 750) aldosterone-to-renin ratio (ARR). CONCLUSION: In this multi-ethnic population, the C-344T CYP1B2 polymorphism is associated with blood pressure, plasma aldosterone levels and ARR. Although significant differences in allele frequencies were found between groups, ethnicity does not explain the results.
Barbato et al. (Thu,) reported a cross-sectional. C-344T CYP11B2 polymorphism (TT genotype) vs. CC genotype was evaluated on Plasma aldosterone levels and blood pressure (14% higher aldosterone, 3.7 mmHg higher SBP, 2.1 mmHg higher DBP, p=< 0.05). The TT genotype of the C-344T CYP11B2 polymorphism was associated with 14% higher plasma aldosterone, 3.7 mmHg higher systolic, and 2.1 mmHg higher diastolic blood pressure compared to CC (P<0.05).