May 8, 2007
View Full PaperAspirin Dose for the Prevention of Cardiovascular Disease
Structured PICO
Does long-term use of aspirin dosages greater than 75 to 81 mg/d improve prevention of cardiovascular events compared to lower doses?
P
Population
Individuals requiring cardiovascular disease prevention
I
Intervention
Aspirin dosages greater than 75 to 81 mg/d (long-term use)
C
Comparator
Aspirin 75 to 81 mg/d
O
Outcome
Cardiovascular eventshard clinical
Routine long-term use of aspirin doses >81 mg/day for CVD prevention offers no additional benefit over lower doses but increases the risk of gastrointestinal bleeding.
Abstract
Currently available clinical data do not support the routine, long-term use of aspirin dosages greater than 75 to 81 mg/d in the setting of cardiovascular disease prevention. Higher dosages, which may be commonly prescribed, do not better prevent events but are associated with increased risks of gastrointestinal bleeding.