Why the study?
Does long-term use of aspirin dosages greater than 75 to 81 mg/d improve prevention of cardiovascular events compared to lower doses?
Does long-term use of aspirin dosages greater than 75 to 81 mg/d improve prevention of cardiovascular events compared to lower doses?
Routine long-term use of aspirin doses >81 mg/day for CVD prevention offers no additional benefit over lower doses but increases the risk of gastrointestinal bleeding.
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Supports low-dose aspirin to limit GI bleeding without efficacy loss; leaves open optimal regimens in high-risk subgroups.
Campbell et al. (2007) studied this question.
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