September 1, 2006Journal of Cardiovascular Pharmacology and Therapeutics
Dose of Aspirin in the Treatment and Prevention of Cardiovascular Disease: Current and Future Directions
Key result
Daily doses of 75 to 325 mg aspirin are sufficient for long-term treatment and prevention of cardiovascular disease, with loading doses of 162.5 to 325 mg necessary in acute settings.
Why the study?
What is the optimal dose of aspirin for the treatment and prevention of cardiovascular disease?
Population
Patients with prior occlusive vascular disease events, acute myocardial infarction, acute occlusive stroke…
Design
Review
Authors
Discussion
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Implication
Guides aspirin dosing in CVD care; confirms prior meta-analyses while leaving optimal regimens open for targeted trials.
Structured PICO
What is the optimal dose of aspirin for the treatment and prevention of cardiovascular disease?
P
Population
Patients with prior occlusive vascular disease events (secondary prevention), acute myocardial infarction, acute occlusive stroke, and primary prevention populations (men and women, including women older than age 65).
I
Intervention
Aspirin at various doses (75 mg to >1500 mg daily for secondary prevention; 162.5 to 325 mg loading dose for acute events; 75 mg daily to 325 mg alternate days for primary prevention).
O
Outcome
Myocardial infarction, stroke, and cardiovascular deathhard clinical
Daily doses of 75 to 325 mg aspirin are sufficient for long-term cardiovascular disease prevention, while a loading dose of 162.5 to 325 mg is needed for acute events.
Cite This Study
Hennekens et al. (2006) conducted a review in Cardiovascular disease. Aspirin was evaluated. Daily doses of 75 to 325 mg aspirin are sufficient for long-term treatment and prevention of cardiovascular disease, with loading doses of 162.5 to 325 mg necessary in acute settings.