Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1996Stroke

Aspirin in Ischemic Cerebrovascular Disease

View Full Paper
Ask AI
Bookmark
Share

Key result

Low-dose aspirin is recommended to prevent stroke and death in ischemic cerebrovascular disease pending ongoing trials.

Why the study?

Does low-dose aspirin compared to high-dose aspirin provide optimal prevention of stroke and death in patients with ischemic cerebrovascular disease?

Population

Patients with ischemic cerebrovascular disease

Comparison

Low-dose aspirin (75 mg daily) vs High-dose aspirin (650 to 1300 mg daily)

Design

Review

Authors

GRGerald J. RothCenter for Infectious Disease Research

Discussion

Loading...

Member takes

Overview

Supports interim low-dose aspirin use in ischemic cerebrovascular disease; leaves open optimal dosing versus higher regimens pending trials.

Structured PICO

Does low-dose aspirin compared to high-dose aspirin provide optimal prevention of stroke and death in patients with ischemic cerebrovascular disease?

P
Population
Patients with ischemic cerebrovascular disease
I
Intervention
Low-dose aspirin (75 mg daily)
C
Comparator
High-dose aspirin (650 to 1300 mg daily)
O
Outcome
Prevention of stroke and deathhard clinical

The review recommends using low-dose aspirin (75 mg daily) for stroke prevention in ischemic cerebrovascular disease due to lack of definitive evidence for higher doses.

Limitations

  • Absence of definitive evidence from direct randomized comparisons of low-dose versus high-dose aspirin in trials of adequate size

Cite This Study

Gerald J. Roth (1996) conducted a review in Ischemic Cerebrovascular Disease. Aspirin vs. Higher doses (650 to 1300 mg) was evaluated on Prevention of stroke and death. Aspirin at a low dose of 75 mg daily is recommended for the prevention of stroke and death in patients with ischemic cerebrovascular disease, pending definitive evidence from ongoing trials.

synapsesocial.com/papers/6aa644077b142bbe3664ca7fhttps://doi.org/10.1161/01.str.27.4.756
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Two Doses of Aspirin (30 mg vs. 283 mg a Day) in Patients after a Transient Ischemic Attack or Minor Ischemic Stroke1991 · 761 citations
  2. 2Dose-dependent effect of aspirin on carotid atherosclerosis.1993 · 87 citations
  3. 3Aspirin as a therapeutic agent in cardiovascular disease. Special Writing Group.1993 · 207 citations
  4. 4High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation.1992 · 152 citations
  5. 5Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients1994 · 3,134 citations