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October 1, 1992StrokeOpen Access

Low-dose aspirin and stroke. "It ain't necessarily so".

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Why the study?

Does low-dose aspirin prevent stroke and death as effectively as high-dose aspirin in patients with TIAs and stroke?

Population

Patients presenting with transient ischemic attacks (TIAs) and stroke

Comparison

Low-dose aspirin (325 mg/day or less) vs High-dose aspirin (greater than 975 mg/day)

Design

Editorial

Authors

MDMark L. DykenIndiana University – Purdue University IndianapolisHBH. J. M. BarnettWestern UniversityJEJ. Donald EastonUniversity of Verona

Discussion

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Implication

The authors challenge the prevailing assumption that low-dose aspirin (≤325 mg/day) is as effective as high-dose aspirin (>975 mg/day) for stroke prevention in patients with TIAs and stroke.

Structured PICO

Does low-dose aspirin prevent stroke and death as effectively as high-dose aspirin in patients with TIAs and stroke?

P
Population
Patients presenting with transient ischemic attacks (TIAs) and stroke
I
Intervention
Low-dose aspirin (325 mg/day or less)
C
Comparator
High-dose aspirin (greater than 975 mg/day)
O
Outcome
Prevention of stroke and deathhard clinical

The authors challenge the prevailing assumption that low-dose aspirin (≤325 mg/day) is as effective as high-dose aspirin (>975 mg/day) for stroke prevention in patients with TIAs and stroke.

Cite This Study

Dyken et al. (1992) studied this question.

synapsesocial.com/papers/6a86f543b688e10ffe82bc7bhttps://doi.org/10.1161/01.str.23.10.1395
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aspirin at any dose above 30 mg offers only modest protection after cerebral ischaemia.1996 · 256 citations
  2. 2The effect of dose of aspirin in high-risk TIA and minor ischemic stroke patients receiving dual antiplatelet medication2026
  3. 3Antiplatelet Agents and Stroke Prevention1998 · 15 citations
  4. 4Aspirin Dosing for the Prevention and Treatment of Ischemic Stroke: An Indication-Specific Review of the Literature2010 · 36 citations
  5. 5Stroke Prevention: Antiplatelet and Antithrombolytic Therapy2000 · 6 citations