The biological half-life of radioactive phosphorus in the blood of patients with leukemia.IV. Leukocytes—radioactive phosphorus content and the relation to plasma-P32 levels

A L T H O U G H a number of reports on short-term studies of the P32 levels in leukocytes have appeared, the purpose of this investigation is to determine the disappearance-time rate of radioactive phosphorus from unit volumes of leukocytes from patients with leukemia, and the correlation of these data with the corresponding plasma-P32 levels in these patients over intervals of time comparable with the period between successive doses of radioactive phosphorus administered for the treatment of leukemia.*have published the most complete studies found on the problem of the time curve of P32 levels in the leukocytes of leukemia patients.Their study extended over a period of eight days and, from the published graphs, it is estimated that the ratio of the leukocyte P32 to that of the plasma P32 was somewhat in excess of 10, with the uptake Erf, Tuttle, and Lawrence2.