Severe obesity (BMI >35 kg/m2) was associated with reduced right ventricular systolic velocity compared to normal-weight referents (6.5 vs. 10.2 cm/s, P<0.001), independent of sleep apnea.
Cross-Sectional (n=148)
Does increasing BMI reduce right ventricular function in subjects without overt heart disease?
Increasing BMI is independently associated with increasing severity of subclinical right ventricular dysfunction in overweight and obese subjects without overt heart disease, irrespective of sleep apnea.
Absolute Event Rate: 6.5% vs 10.2%
p-value: p=<0.001
OBJECTIVES: The purpose of this research was to identify the determinants of right ventricular (RV) dysfunction in overweight and obese subjects. BACKGROUND: Right ventricular dysfunction in obese subjects is usually ascribed to comorbid diseases, especially obstructive sleep apnea. We used tissue Doppler imaging to identify the determinants of RV dysfunction in overweight and obese subjects. METHODS: Standard and tissue Doppler echocardiography was performed in 112 overweight (body mass index BMI 25 to 29.9 kg/m2) or obese (BMI >30 kg/m2) subjects and 36 referents (BMI 35 kg/m2 had reduced RV function compared with referent subjects, evidenced by reduced s(m) (6.5 +/- 2.4 cm/s vs. 10.2 +/- 1.5 cm/s, p < 0.001), peak strain (-21 +/- 4% vs. -28 +/- 4%, p < 0.001), peak strain rate (-1.4 +/- 0.4 s(-1) vs. -2.0 +/- 0.5 s(-1), p < 0.001), and e(m) (-6.8 +/- 2.4 cm/s vs. -10.3 +/- 2.5 cm/s, p < 0.001), irrespective of the presence of sleep apnea. Similar but lesser degrees of reduced systolic function (p < 0.05) were present in overweight (BMI 25 to 29.9 kg/m2) and mildly obese (BMI 30 to 35 kg/m2) groups. Differences in RV e(m), s(m), and strain indexes were demonstrated between the severely versus overweight and mildly obese groups (p < 0.05). Body mass index remained independently related to RV changes after adjusting for age, log insulin, and mean arterial pressures. In obese patients, these changes were associated with reduced exercise capacity but not the duration of obesity and presence of sleep apnea or its severity. CONCLUSIONS: Increasing BMI is associated with increasing severity of RV dysfunction in overweight and obese subjects without overt heart disease, independent of sleep apnea.
Wong et al. (Thu,) conducted a cross-sectional in Obesity (n=148). Severe obesity (BMI >35 kg/m2) vs. Normal weight (BMI <25 kg/m2) was evaluated on Right ventricular systolic velocity (s(m)) (p=<0.001). Severe obesity (BMI >35 kg/m2) was associated with reduced right ventricular systolic velocity compared to normal-weight referents (6.5 vs. 10.2 cm/s, P<0.001), independent of sleep apnea.