August 15, 2014Open Access

Early Development of Calcific Aortic Valve Disease and Left Ventricular Hypertrophy in a Mouse Model of Combined Dyslipidemia and Type 2 Diabetes Mellitus

Structured PICO

Population

diabetes mellitus-prone LDLr(-/-)/ApoB(100/100)/IGF-II mouse model

Outcome

development of calcific aortic valve disease and left ventricular hypertrophysurrogate

The LDLr(-/-)/ApoB(100/100)/IGF-II mouse serves as a novel preclinical model demonstrating that type 2 diabetes and dyslipidemia contribute to early aortic valve calcification.

Abstract

We have established the diabetes mellitus -prone LDLr(-/-)/ApoB(100/100)/IGF-II mouse as a new model of calcified aortic valve disease. Our results are consistent with the growing body of clinical evidence that the dysmetabolic state of type 2 diabetes mellitus contributes to early mineralization of the aortic valve and calcified aortic valve disease pathogenesis.

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Cite This Study

Quang et al. (Fri,) studied this question.

synapsesocial.com/papers/69b31ef095ae609a79650199 https://doi.org/https://doi.org/10.1161/atvbaha.114.304205

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