Higher body mass index was associated with an average 14% increase in coronary heart disease risk for each 2 kg/m2 increase in BMI among larger prospective cohort studies.
Systematic Review
Is higher body mass index associated with an increased risk of coronary heart disease?
Higher body mass index is consistently associated with an increased risk of coronary heart disease, an effect likely mediated by hypertension, dyslipidemia, and impaired glucose tolerance.
Effect estimate: 14% increase per 2 kg/m2
We systematically reviewed English-language publications arising from prospective cohort studies of the association between coronary heart disease risk and body mass index. Eighty published articles from 46 studies were identified. Two thirds of the studies, including all 14 studies with at least 500 cases ("larger" studies), reported a positive or J-shaped association. Among these 14 larger studies, the average increase in coronary heart disease risk for each 2 kg/m (2) higher body mass index was 14%. There was only limited evidence of effect modification by age, sex, ethnicity, or other variables. Evidence from many studies, including randomized controlled trials, implies that the association between coronary heart disease risk and body mass index is partly (or perhaps wholly) mediated by high blood pressure, dyslipidemia, and impaired glucose tolerance.
Whitlock et al. (Tue,) conducted a systematic review in Coronary Heart Disease. Body Mass Index was evaluated on Coronary heart disease risk (14% increase per 2 kg/m2). Higher body mass index was associated with an average 14% increase in coronary heart disease risk for each 2 kg/m2 increase in BMI among larger prospective cohort studies.
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