July 31, 2008

Preoperative Use of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Is Associated with Increased Risk for Acute Kidney Injury after Cardiovascular Surgery

Structured PICO

Does preoperative use of ACEI/ARB increase the risk of postoperative acute kidney injury in patients undergoing cardiovascular surgery?

Population

Patients undergoing cardiovascular surgery

Intervention

Preoperative use of Angiotensin-Converting Enzyme Inhibitors (ACEI) or Angiotensin Receptor Blockers (ARB)

Comparator

Stopping or not using ACEI/ARB before cardiac surgery

Outcome

Acute Kidney Injury (AKI) postoperativelysafety

Preoperative use of ACEI/ARBs is associated with a 27.6% increased risk of postoperative acute kidney injury in cardiovascular surgery patients, suggesting that withholding these medications prior to surgery may be beneficial.

Abstract

Preoperative use of ACEI/ARB is associated with a 27.6% higher risk for AKI postoperatively. Stopping ACEI or ARB before cardiac surgery may reduce the incidence of AKI.

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