Why the study?
Does preoperative use of ACEI/ARB increase the risk of postoperative acute kidney injury in patients undergoing cardiovascular surgery?
Population
Patients undergoing cardiovascular surgery
Comparison
Preoperative use of Angiotensin-Converting… vs Stopping or not using ACEI/ARB before cardiac…
Design
Cohort
Follow-up
postoperatively
Authors
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Suggests caution with preoperative ACEI/ARB in cardiovascular surgery; hypothesis-generating for RCTs on withholding.
Does preoperative use of ACEI/ARB increase the risk of postoperative acute kidney injury in patients undergoing cardiovascular surgery?
Preoperative use of ACEI/ARBs is associated with a 27.6% increased risk of postoperative acute kidney injury in cardiovascular surgery patients, suggesting that withholding these medications prior to surgery may be beneficial.
Arora et al. (2008) studied this question.
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