Muscle biopsy analysis in a 65-year-old woman with suspected dermatomyositis revealed numerous nemaline rods and abnormalities in myosin light chain and tropomyosin protein patterns.
Case Report (n=1)
This case report identifies adult-onset nemaline rods and specific protein abnormalities in a patient presenting with symptoms initially suspected to be dermatomyositis.
• A 65-year-old woman with progressive muscle weakness and a diffuse rash of three years' duration was examined. Muscle tissue was studied with histochemical techniques, phase-contrast microscopy, electron microscopy, and twodimensional electrophoresis. Histochemical studies showed numerous nemaline rods, with a normal ratio of types I and II fibers. Two-dimensional electrophoresis revealed abnormalities in the myosin light chain and tropomyosin protein patterns when compared with normal and diseased muscle biopsy samples, including those from two patients with adult-onset dermatomyositis.
Moris J. Danon (Tue,) conducted a case report in Suspected Dermatomyositis with Adult-Onset Nemaline Rods (n=1). Muscle biopsy and analysis (histochemical, microscopy, two-dimensional electrophoresis) vs. Normal and diseased muscle biopsy samples (including adult-onset dermatomyositis) was evaluated on Muscle tissue abnormalities. Muscle biopsy analysis in a 65-year-old woman with suspected dermatomyositis revealed numerous nemaline rods and abnormalities in myosin light chain and tropomyosin protein patterns.