Tim-3 displays critical roles in microenvironment-induced activation and protumoral effects of TAMs in HCC. Interference of Tim-3 might be great potential in HCC therapy.

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Yan et al. (Wed,) studied this question.

synapsesocial.com/papers/69df3e806324afb55d5919f3 https://doi.org/https://doi.org/10.1136/gutjnl-2014-307671

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1TGF-β in progression of liver disease2011 · 720 citations
2IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men1999 · 326 citations
3Improved Survival with Ipilimumab in Patients with Metastatic Melanoma2010 · 15,163 citations
4Hepatocellular Carcinoma: Epidemiology, Surveillance, and Diagnosis2010 · 398 citations
5Tumour-educated macrophages promote tumour progression and metastasis2004 · 3,368 citations