The ACE gene I/D polymorphism was significantly associated with hypertension, with allele and genotype frequencies differing significantly between hypertensive patients and controls (p < 0.01).
Case-Control (n=103)
Is the ACE gene I/D polymorphism associated with hypertension and blood pressure levels in the Bangladeshi population?
The ACE gene DD genotype is significantly associated with hypertension and higher blood pressure in the Bangladeshi population, particularly in men.
p-value: p=<0.01
The genetic factors that contribute to the development of coronary artery disease (CAD) are poorly understood. It is likely that multiple genes that act independently or synergistically contribute to the development of CAD and the outcome. Recently, an insertion/deletion (I/D) polymorphism of the human angiotensin I-converting enzyme (ACE) gene, a major component of the reninangiotensin system (RAS), was identified. The association of the ACE gene D allele with essential hypertension and CAD has been reported in the African-American, Chinese, and Japanese populations. However, other studies have failed to detect such an association. It has been suggested that these inconsistencies may be due to the difference in backgrounds of the population characteristics. In the present study, we investigated the I/D polymorphism of the ACE gene in 103 subjects of both sexes, consisting of 59 normal controls and 44 patients with hypertension. The allele and genotype frequency were significantly different between the hypertensive and control groups (p < 0.01). Among the three ACE I/D variants, the DD genotype was associated with the highest value of the mean systolic blood pressure SBP and mean diastolic blood pressure DBP (p = < 0.05) in men, but not in women. In the overall population, the mean SBP and DBP was highest in DD subjects, intermediate in I/D subjects, and the least in II subjects
Morshed et al. (Fri,) conducted a case-control in Hypertension (n=103). ACE gene I/D polymorphism vs. Normal controls was evaluated on Allele and genotype frequency (p=<0.01). The ACE gene I/D polymorphism was significantly associated with hypertension, with allele and genotype frequencies differing significantly between hypertensive patients and controls (p < 0.01).
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