Measuring total pulmonary arterial compliance using MR flow data and invasive pressure measurements is feasible, demonstrating good agreement between two estimation methods (r=0.98, P<0.001).
Observational (n=17)
Can total pulmonary arterial compliance be quantified using MR flow data and invasive pressure measurements in patients with suspected pulmonary hypertension or congenital heart disease?
The study demonstrates the feasibility of quantifying total pulmonary arterial compliance using MR flow quantification combined with invasive pressure monitoring during MR-guided cardiac catheterization.
Effect estimate: r = 0.98
p-value: p=<0.001
Pulmonary hypertensive disease is assessed by quantification of pulmonary vascular resistance. Pulmonary total arterial compliance is also an indicator of pulmonary hypertensive disease. However, because of difficulties in measuring compliance, it is rarely used. We describe a method of measuring pulmonary arterial compliance utilizing magnetic resonance (MR) flow data and invasive pressure measurements. Seventeen patients with suspected pulmonary hypertension or congenital heart disease requiring preoperative assessment underwent MR-guided cardiac catheterization. Invasive manometry was used to measure pulmonary arterial pressure, and phase-contrast MR was used to measure flow at baseline and at 20 ppm nitric oxide (NO). Total arterial compliance was calculated using the pulse pressure method (parameter optimization of the 2-element windkessel model) and the ratio of stroke volume to pulse pressure. There was good agreement between the two estimates of compliance (r = 0.98, P 10% in response to 20 ppm NO. As a population, the increase did not reach statistical significance. There was an inverse relation between compliance and resistance (r = 0.89, P < 0.001) and between compliance and mean pulmonary arterial pressure (r = 0.72, P < 0.001). We have demonstrated the feasibility of quantifying total arterial compliance using an MR method.
Muthurangu et al. (Sat,) conducted a observational in Suspected pulmonary hypertension or congenital heart disease (n=17). MR-guided cardiac catheterization with nitric oxide vs. Baseline was evaluated on Agreement between pulse pressure method and stroke volume to pulse pressure ratio for estimating total arterial compliance (r = 0.98, p=<0.001). Measuring total pulmonary arterial compliance using MR flow data and invasive pressure measurements is feasible, demonstrating good agreement between two estimation methods (r=0.98, P<0.001).
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